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Product Name
Human WWP2 (His & GST Tag) recombinant protein
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Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
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Protein name
NEDD4-like E3 ubiquitin-protein ligase WWP2
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Protein short names
NEDD-4-LIKE UBIQUITIN-PROTEIN LIGASE; AW554328; WW DOMAIN-CONTAINING PROTEIN 2; NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2; WWP2-LIKE; WW DOMAIN-CONTAINING PROTEIN 4; 1300010O06RIK; AA690238; AIP2; ATROPHIN-1 INTERACTING PROTEIN 2
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Uniprot ID
O00308
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Gene Name
WWP2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human WWP2 (O00308) (Met1-Glu870) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human WWP2 /GST chimera consists of 1107 amino acids and has a calculated molecular mass of 126.7 kDa. The recombinant protein migrates as an approximately 120 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human WWP2 Protein (His & GST Tag) SDS-PAGE
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