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Product Name
Human TRIM24 Recombinant protein (His tag)
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Description
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {, PubMed:16322096, PubMed:19556538, PubMed:21164480}.
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Protein name
Transcription intermediary factor 1-alpha
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Protein short names
RNF82; TIF1; TIF1A
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Uniprot ID
O15164
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Gene Name
TRIM24; RNF82; TIF1; TIF1A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human TRIM24 (NP_056989.2) 701-1050 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TRIM24 SDS-PAGE
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