Human TBC1D5 Recombinant protein (GST tag)

Human TBC1D5 Recombinant protein (GST tag)

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May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {PubMed:19531583, PubMed:20923837, PubMed:22354992, PubMed:24603492, PubMed:19531583, PubMed:22354992, PubMed:24603492}.

TBC1 domain family member 5

KIAA0210

Q92609

TBC1D5; KIAA0210

E. coli

A DNA sequence encoding the human TBC1D5 (NP_001336010.1) 452-802 aa was fused with the N-terminal GST tag

Human

Not tested.