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Product Name
Human KEAP1 (His & GST & AVI Tag) recombinant protein
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Description
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:17046835}.
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Protein name
Kelch-like ECH-associated protein 1
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Protein short names
INRF2; KIAA0132; KLHL19
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Uniprot ID
Q14145
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Gene Name
KEAP1; INRF2; KIAA0132; KLHL19
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KEAP1 (Q14145) (Gln 2-Cys 624) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus linked by the AVI tag.
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Protein Species
Human
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Molecular weight
The recombinant human KEAP1/GST chimera consists of 875 amino acids and has a calculated molecular mass of 99.2 kDa. It migrates as an approximately 85 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human KEAP1 / INRF2 Protein (His & GST & AVI Tag) SDS-PAGE
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