Human CARKL / SHPK recombinant protein

Cat.#: 503758

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Product Information

  • Product Name
    Human CARKL / SHPK recombinant protein
  • Documents
  • Description
    CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and uncover a rate-limiting requirement for appropriate glucose flux in macrophage polarization.
  • Protein name
    Transient receptor potential cation channel subfamily V member 1
  • Protein short names
    AI194947; SHPK; AW260459; RP23-214D6.1; 4930431K22RIK; CARBOHYDRATE KINASE-LIKE PROTEIN; SHK; CARKL; SEDOHEPTULOKINASE
  • Uniprot ID
    Q9UHJ6
  • Gene Name
    TRPV1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SHPK (NP_037408.2) (Ala2-Ser478) was fused with two additional amino acids (Gly&Pro) at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human SHPK consists of 479 amino acids and has a calculated molecular mass of 51.5 kDa. The recombinant protein migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human CARKL / SHPK Protein SDS-PAGE

    Human CARKL / SHPK Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"