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Product Name
Human GSTZ1 (His Tag) recombinant protein
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Description
GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein which has minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. GSTZ1 catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. GSTZ1 participates in the catabolism of phenylalanine and tyrosine. Thus defects in GSTZ1 cause harsh metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia.
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Protein name
Glutathione transferase zeta 1 (Maleylacetoacetate isomerase), isoform CRA_c
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Protein short names
GLUTATHIONE S-ARALKYLTRANSFERASE; GLUTATHIONE S-ALKYLTRANSFERASE; GLUTATHIONE S-TRANSFERASE ZETA 1; S-(HYDROXYALKYL)GLUTATHIONE LYASE; MALEYLACETOACETATE ISOMERASE; MAAI; GLUTATHIONE S-ARYLTRANSFERASE; MAI; GSTZ1-1; MALEYLACETONE ISOMERASE; GSTZ1; GLUTATHIONE TRANSFERASE ZETA 1; GLUTATHIONE TRANSFERASE ZETA 1 (MALEYLACETOACETATE ISOMERASE)
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Uniprot ID
O43708
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Gene Name
GSTZ1; hCG_22265
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human GSTZ1 (NP_665877.1) (Met1-Ala216) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GSTZ1 consists of 231 amino acids and predicts a molecular mass of 26 KDa. It migrates as an approximately 27 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human GSTZ1 Protein (His Tag) SDS-PAGE
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