-
Product Name
CREST antibody
- Documents
-
Description
CREST Mouse Monoclonal antibody. Positive WB detected in MCF-7 cells. Observed molecular weight by Western-blot: 55 kDa
-
Tested applications
ELISA, WB
-
Species reactivity
Human; other species not tested.
-
Alternative names
CREST antibody; KIAA0693 antibody; LP2261 antibody; SS18 like protein 1 antibody; SS18L1 antibody; SYT homolog 1 antibody
- Immunogen
-
Isotype
Mouse IgG1
-
Preparation
This antibody was obtained by immunization of CREST recombinant protein (Accession Number: NM_015558). Purification method: Protein G purified.
-
Clonality
Monoclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
-
Validations
MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107176(CREST Antibody) at dilution of 1:500
-
Background
SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"