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Product Name
BCRP/ABCG2 antibody
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Description
BCRP/ABCG2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IHC detected in human meningioma tissue, human gliomas tissue. Observed molecular weight by Western-blot: 60-70 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
ABC15 antibody; ABCG2 antibody; ABCP antibody; BCRP antibody; BMDP antibody; CD338 antibody; CDw338 antibody; EST157481 antibody; MRX antibody; MXR antibody; MXR1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of BCRP/ABCG2 recombinant protein (Accession Number: NM_004827). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:117110(BCRP,ABCG2 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human meningioma tissue slide using Catalog No:117110(BCRP,ABCG2 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human meningioma tissue slide using Catalog No:117110(BCRP,ABCG2 Antibody) at dilution of 1:50 (under 40x lens)
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Background
BCRP (breast cancer resistance protein) confers a broad spectrum of drug resistance and the expression of BCRP is enhanced in several cancer cell models. It has ATPase activity and belongs to a family of multiple drug resistant proteins. Data also indicated that BCRP might be an early marker for some stem cells.
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References
- Wang H, Lee EW, Cai X, Ni Z, Zhou L, Mao Q. Membrane topology of the human breast cancer resistance protein (BCRP/ABCG2) determined by epitope insertion and immunofluorescence. Biochemistry. 47(52):13778-87. 2008.
- Yamasaki T, Kawamura K, Hatori A. PET study on mice bearing human colon adenocarcinoma cells using
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