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Product Name
Anti-BACE1 Rabbit antibody
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Description
BACE1 Rabbit monoclonal antibody
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Tested applications
WB, IP
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Species reactivity
Mouse, Rat
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Alternative names
ASP2; Bace; C76936 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of mouse BACE1
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
IP: 1/20
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Validations
Western blot detection of BACE1 in Rat Brain lysates using BACE1 Rabbit mAb(1:1000 diluted).Predicted band size:56kDa.Observed band size:70kDa.
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Background
Swiss-Prot Acc.P56818.Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"