LOCUS       V002344                12865 bp    DNA     circular SYN 18-DEC-2018
DEFINITION  Exported.
ACCESSION   V002344
VERSION     V002344
KEYWORDS    .
SOURCE      synthetic DNA construct
  ORGANISM  synthetic DNA construct
            .
REFERENCE   1  (bases 1 to 12865)
  AUTHORS   Koopman F, Beekwilder J, Crimi B, Houwelingen A, Hall RD, Bosch D,
            van Maris AJ, Pronk JT, Daran JM.
  TITLE     De novo production of the flavonoid naringenin in engineered
            Saccharomyces cerevisiae
  JOURNAL   Microb. Cell Fact. 11 (1), 155 (2012)
   PUBMED   23216753
REFERENCE   2  (bases 1 to 12865)
  AUTHORS   Koopman F, Beekwilder J, Crimi B, van Houwelingen A, Hall RD, Bosch
            D, Maris AJA., Pronk JT, Daran J-M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2012) Platform Green Synthetic Biolog, Delft 2600,
            The Netherlands
REFERENCE   3  (bases 1 to 12865)
  TITLE     Direct Submission
REFERENCE   4  (bases 1 to 12865)
  AUTHORS   .
  TITLE     Direct Submission
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Microb.
            Cell Fact."; date: "2012"; volume: "11"; issue: "1"; pages: "155"
            SGRef: number: 2; type: "Journal Article"; journalName: "Submitted
            (02-JUL-2012) Platform Green Synthetic Biolog, Delft 2600, The
            Netherlands"
            SGRef: number: 3; type: "Journal Article"
FEATURES             Location/Qualifiers
     source          1..12865
                     /mol_type="other DNA"
                     /organism="synthetic DNA construct"
     promoter        8..651
                     /label="GAP promoter"
                     /note="promoter for glyceraldehyde-3-phosphate
                     dehydrogenase; also known as the TDH3 promoter"
     CDS             657..2831
                     /gene="PAL1"
                     /label="Phenylalanine ammonia-lyase 1"
                     /note="Phenylalanine ammonia-lyase 1 from Arabidopsis
                     thaliana. Accession#: P35510"
     terminator      2835..3082
                     /label="CYC1 terminator"
                     /note="transcription terminator for CYC1"
     misc_feature    3090..3169
                     /label="recombination site B"
                     /note="recombination site B"
     promoter        3571..4078
                     /label="TPI1 promoter"
                     /note="strong constitutive promoter for yeast triose
                     phosphate isomerase"
     CDS             4078..5592
                     /gene="CYP73A5"
                     /label="Trans-cinnamate 4-monooxygenase"
                     /note="Trans-cinnamate 4-monooxygenase from Arabidopsis
                     thaliana. Accession#: P92994"
     terminator      5734..5921
                     /label="ADH1 terminator"
                     /note="transcription terminator for the S. cerevisiae
                     alcohol dehydrogenase 1 (ADH1) gene"
     misc_feature    6063..6142
                     /label="recombination site C"
                     /note="recombination site C"
     regulatory      6146..6520
                     /label="PGI1 promoter"
                     /note="PGI1 promoter"
                     /regulatory_class="promoter"
     CDS             6527..8602
                     /gene="ATR1"
                     /label="NADPH--cytochrome P450 reductase 1"
                     /note="NADPH--cytochrome P450 reductase 1 from Arabidopsis
                     thaliana. Accession#: Q9SB48"
     regulatory      8611..8877
                     /operon="PGI1 terminator"
                     /regulatory_class="terminator"
     misc_feature    8917..8996
                     /label="recombination site D"
                     /note="recombination site D"
     CDS             complement(9129..9929)
                     /label="URA3"
                     /note="orotidine-5'-phosphate decarboxylase, required for
                     uracil biosynthesis"
     promoter        complement(9930..10150)
                     /label="URA3 promoter"
     misc_feature    complement(10415..10918)
                     /label="CEN/ARS"
                     /note="S. cerevisiae CEN6 centromere fused to an
                     autonomously replicating sequence"
     promoter        10955..11059
                     /label="AmpR promoter"
     CDS             11060..11917
                     /label="AmpR"
                     /note="beta-lactamase"
     rep_origin      12091..12679
                     /direction=RIGHT
                     /label="ori"
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of
                     replication"
     misc_feature    12784..12863
                     /label="recombination site A"
                     /note="recombination site A"
ORIGIN
        1 tagtttatca ttatcaatac tcgccatttc aaagaatacg taaataatta atagtagtga
       61 ttttcctaac tttatttagt caaaaaatta gccttttaat tctgctgtaa cccgtacatg
      121 cccaaaatag ggggcgggtt acacagaata tataacatcg taggtgtctg ggtgaacagt
      181 ttattcctgg catccactaa atataatgga gcccgctttt taagctggca tccagaaaaa
      241 aaaagaatcc cagcaccaaa atattgtttt cttcaccaac catcagttca taggtccatt
      301 ctcttagcgc aactacagag aacaggggca caaacaggca aaaaacgggc acaacctcaa
      361 tggagtgatg caacctgcct ggagtaaatg atgacacaag gcaattgacc cacgcatgta
      421 tctatctcat tttcttacac cttctattac cttctgctct ctctgatttg gaaaaagctg
      481 aaaaaaaagg ttgaaaccag ttccctgaaa ttattcccct acttgactaa taagtatata
      541 aagacggtag gtattgattg taattctgta aatctatttc ttaaacttct taaattctac
      601 ttttatagtt agtctttttt ttagttttaa aacaccagaa cttagtttcg acggatatgg
      661 agattaacgg ggcacacaag agcaacggag gaggagtgga cgctatgtta tgcggcggag
      721 acatcaagac aaagaacatg gtgatcaacg cggaggatcc tctcaactgg ggagctgcag
      781 cggagcaaat gaaaggtagc catttggatg aagtgaagag aatggttgct gagtttagga
      841 agccagttgt gaatcttggt ggtgagactc tgaccattgg acaagtggct gcgatctcaa
      901 ctattggtaa cagtgtgaag gtggagctat cggagacagc tagagccggt gtgaatgcta
      961 gtagtgattg ggttatggag agtatgaaca aaggcactga tagttatggt gttactactg
     1021 gttttggtgc tacttctcat cggagaacca aaaacggtgt cgcacttcag aaggaactta
     1081 ttagattcct taacgccgga atattcggaa gcacgaaaga aacaagccac acattgccac
     1141 actccgccac aagagccgcc atgcttgtac gaatcaacac tctcctccaa ggattttccg
     1201 gtatccgatt tgagattctc gaagcaatta ccagtttcct caacaacaac atcactccat
     1261 ctctccccct ccgtggtaca atcaccgcct ccggagatct cgttcctctc tcctacatcg
     1321 ccggacttct caccggtcgt cccaattcca aagctactgg tcccaacggt gaagctttaa
     1381 cagcagagga agctttcaaa ttagcaggaa tcagctccgg attctttgat ctccagccta
     1441 aggaaggtct cgcgctagtc aatggcacgg cggttggatc tggaatggcg tcaatggtgt
     1501 tattcgaaac gaatgttctc tctgttttgg ctgagatttt gtcggcggtt ttcgcagagg
     1561 tgatgagtgg taagcctgag ttcaccgatc atctcactca cagacttaaa catcatcccg
     1621 gtcaaatcga agcggcggcg ataatggagc atatcctcga cggaagctcg tacatgaaat
     1681 tagctcagaa gcttcacgag atggatccgt tacagaaacc taaacaagat cgttacgctc
     1741 ttcgtacttc tcctcaatgg ttaggtcctc aaatcgaagt gatccgttac gcaacgaaat
     1801 cgatcgagcg tgagattaac tccgtcaacg ataatccgtt gatcgatgtt tcgaggaaca
     1861 aggcgattca cggtggtaac ttccaaggaa caccaatcgg agtttcaatg gataacacga
     1921 gattggcgat agcagcgatt ggtaaactca tgtttgctca attctcagag cttgtgaatg
     1981 atttctacaa caatggttta ccctcgaatc taaccgcttc gaggaatcca agtttggatt
     2041 atggattcaa gggagctgag attgcaatgg cttcttattg ttcagagctt caatacttag
     2101 ctaatcctgt gactagccat gttcaatcag cagagcaaca taaccaagat gtcaactctt
     2161 tgggactaat ctcgtctcgc aaaacttctg aagctgttga tattctcaag cttatgtcaa
     2221 caacgttcct cgttgcgatt tgtcaagctg tggatttgag acatttggag gagaatttga
     2281 gacagactgt gaagaacact gtctctcaag tggcgaagaa agttcttact actggagtca
     2341 atggtgagct tcatccttct cgcttctgcg aaaaggattt actcaaagtt gtagaccgtg
     2401 aacaagtcta cacatacgcg gatgatcctt gtagcgcaac gtacccgttg attcagaagc
     2461 tgagacaagt tattgttgac catgctttga tcaatggtga gagtgagaag aatgcagtga
     2521 cttcaatctt ccataagatt ggagctttcg aggaggagct taaggcagtg ctaccgaaag
     2581 aagtggaagc agcaagagca gcctacgata acggaacatc ggctatcccg aacaggatca
     2641 aggaatgtag gtcgtatcca ttgtatagat tcgtgaggga agagcttgga acagagcttt
     2701 tgaccggaga gaaagtgacg tcgcctggag aagagttcga caaggttttc acggcgattt
     2761 gtgaaggtaa aatcattgat ccgatgatgg aatgtctcaa cgagtggaac ggagctccca
     2821 ttccaatatg ttaatcatgt aattagttat gtcacgctta cattcacgcc ctccccccac
     2881 atccgctcta accgaaaagg aaggagttag acaacctgaa gtctaggtcc ctatttattt
     2941 ttttatagtt atgttagtat taagaacgtt atttatattt caaatttttc ttttttttct
     3001 gtacagacgc gtgtacgcat gtaacattat actgaaaacc ttgcttgaga aggttttggg
     3061 acgctcgaag gctttaattt gcggccatca tactgacagc acgcatggca ggcatactac
     3121 acagattccc actatatgtc aacaggcacc cgcataccga attgctatag atctacgtat
     3181 ggtcatttct tcttcagatt ccctcatgga gaaagtgcgg cagatgtata tgacagagtc
     3241 gccagtttcc aagagacttt attcaggcac ttccatgata ggcaagagag aagacccaga
     3301 gatgttgttg tcctagttac acatggtatt tattccagag tattcctgat gaaatggttt
     3361 agatggacat acgaagagtt tgaatcgttt accaatgttc ctaacgggag cgtaatggtg
     3421 atggaactgg acgaatccat caatagatac gtcctgagga ccgtgctacc caaatggact
     3481 gattgtgagg gagacctaac tacatagtgt ttaaagatta cggatattta acttacttag
     3541 aataatgcca tttttttgag ttataataat cctacgttag tgtgagcggg atttaaactg
     3601 tgaggacctt aatacattca gacacttctg cggtatcacc ctacttattc ccttcgagat
     3661 tatatctagg aacccatcag gttggtggaa gattacccgt tctaagactt ttcagcttcc
     3721 tctattgatg ttacacctgg acaccccttt tctggcatcc agtttttaat cttcagtggc
     3781 atgtgagatt ctccgaaatt aattaaagca atcacacaat tctctcggat accacctcgg
     3841 ttgaaactga caggtggttt gttacgcatg ctaatgcaaa ggagcctata tacctttggc
     3901 tcggctgctg taacagggaa tataaagggc agcataattt aggagtttag tgaacttgca
     3961 acatttacta ttttcccttc ttacgtaaat atttttcttt ttaattctaa atcaatcttt
     4021 ttcaattttt tgtttgtatt cttttcttgc ttaaatctat aactacaaaa aacacatatg
     4081 gacttgttgt tgttggaaaa gtctttgatc gctgttttcg ttgctgttat cttggctact
     4141 gttatctcta agttgagagg taagaagttg aagttgccac caggtccaat cccaatccca
     4201 atcttcggta actggttgca agttggtgac gacttgaacc acagaaactt ggttgactac
     4261 gctaagaagt tcggtgactt gttcttgttg agaatgggtc aaagaaactt ggttgttgtt
     4321 tcttctccag acttgactaa ggaagttttg ttgactcaag gtgttgaatt cggttctaga
     4381 actagaaacg ttgttttcga catcttcact ggtaagggtc aagacatggt tttcactgtt
     4441 tacggtgaac actggagaaa gatgagaaga atcatgactg ttccattctt cactaacaag
     4501 gttgttcaac aaaacagaga aggttgggaa ttcgaagctg cttctgttgt tgaagacgtt
     4561 aagaagaacc cagactctgc tactaagggt atcgttttga gaaagagatt gcaattgatg
     4621 atgtacaaca acatgttcag aatcatgttc gacagaagat tcgaatctga agacgaccca
     4681 ttgttcttga gattgaaggc tttgaacggt gaaagatcta gattggctca atctttcgaa
     4741 tacaactacg gtgacttcat cccaatcttg agaccattct tgagaggtta cttgaagatc
     4801 tgtcaagacg ttaaggacag aagaatcgct ttgttcaaga agtacttcgt tgacgaaaga
     4861 aagcaaatcg cttcttctaa gccaactggt tctgaaggtt tgaagtgtgc tatcgaccac
     4921 atcttggaag ctgaacaaaa gggtgaaatc aacgaagaca acgttttgta catcgttgaa
     4981 aacatcaacg ttgctgctat cgaaactact ttgtggtcta tcgaatgggg tatcgctgaa
     5041 ttggttaacc acccagaaat ccaatctaag ttgagaaacg aattggacac tgttttgggt
     5101 ccaggtgttc aagttactga accagacttg cacaagttgc catacttgca agctgttgtt
     5161 aaggaaactt tgagattgag aatggctatc ccattgttgg ttccacacat gaacttgcac
     5221 gacgctaagt tggctggtta cgacatccca gctgaatcta agatcttggt taacgcttgg
     5281 tggttggcta acaacccaaa ctcttggaag aagccagaag aattcagacc agaaagattc
     5341 ttcgaagaag aatctcacgt tgaagctaac ggtaacgact tcagatacgt tccattcggt
     5401 gttggtagaa gatcttgtcc aggtatcatc ttggctttgc caatcttggg tatcactatc
     5461 ggtagaatgg ttcaaaactt cgaattgttg ccaccaccag gtcaatctaa ggttgacact
     5521 tctgaaaagg gtggtcaatt ctctttgcac atcttgaacc actctatcat cgttatgaag
     5581 ccaagaaact gttaagaagc tttggacttc ttcgccagag gtttggtcaa gtctccaatc
     5641 aaggttgtcg gcttgtctac cttgccagaa atttacgaaa agatggaaaa gggtcaaatc
     5701 gttggtagat acgttgttga cacttctaaa taagcgaatt tcttatgatt tatgattttt
     5761 attattaaat aagttataaa aaaaataagt gtatacaaat tttaaagtga ctcttaggtt
     5821 ttaaaacgaa aattcttatt cttgagtaac tctttcctgt aggtcaggtt gctttctcag
     5881 gtatagcatg aggtcgctct tattgaccac acctctaccg gcatgccgag caaatgcctg
     5941 caaatcgctc cccatttcac ccaattgtag atatgctaac tccagcaatg agttgatgaa
     6001 tctcggtgtg tattttatgt cctcagagga caacacctgt tgtaatcgtt cttccacaca
     6061 tcgacatatc agcatacatg gcgagtgatc catacacatt cccagtaatc agaagctcgc
     6121 acccgcatac cgaattgcta tagatcgtgg gtgtattgga ttataggaag ccacgcgctc
     6181 aacctggaat tacaggaagc tggtaatttt ttgggtttgc aatcatcacc atctgcacgt
     6241 tgttataatg tcccgtgtct atatatatcc attgacggta ttctattttt ttgctattga
     6301 aatgagcgtt ttttgttact acaattggtt ttacagacgg aattttccct atttgtttcg
     6361 tcccattttt ccttttctca ttgttctcat atcttaaaaa ggtcctttct tcataatcaa
     6421 tgctttcttt tacttaatat tttacttgca ttcagtgaat tttaatacat attcctctag
     6481 tcttgcaaaa tcgatttaga atcaagatac cagcctaaaa agatctatga cttctgcttt
     6541 gtacgcttct gacttgttca agcaattgaa gtctatcatg ggtactgact ctttgtctga
     6601 cgacgttgtt ttggttatcg ctactacttc tttggctttg gttgctggtt tcgttgtttt
     6661 gttgtggaag aagactactg ctgacagatc tggtgaattg aagccattga tgatcccaaa
     6721 gtctttgatg gctaaggacg aagacgacga cttggacttg ggttctggta agactagagt
     6781 ttctatcttc ttcggtactc aaactggtac tgctgaaggt ttcgctaagg ctttgtctga
     6841 agaaatcaag gctagatacg aaaaggctgc tgttaaggtt atcgacttgg acgactacgc
     6901 tgctgacgac gaccaatacg aagaaaagtt gaagaaggaa actttggctt tcttctgtgt
     6961 tgctacttac ggtgacggtg aaccaactga caacgctgct agattctaca agtggttcac
     7021 tgaagaaaac gaaagagaca tcaagttgca acaattggct tacggtgttt tcgctttggg
     7081 taacagacaa tacgaacact tcaacaagat cggtatcgtt ttggacgaag aattgtgtaa
     7141 gaagggtgct aagagattga tcgaagttgg tttgggtgac gacgaccaat ctatcgaaga
     7201 cgacttcaac gcttggaagg aatctttgtg gtctgaattg gacaagttgt tgaaggacga
     7261 agacgacaag tctgttgcta ctccatacac tgctgttatc ccagaataca gagttgttac
     7321 tcacgaccca agattcacta ctcaaaagtc tatggaatct aacgttgcta acggtaacac
     7381 tactatcgac atccaccacc catgtagagt tgacgttgct gttcaaaagg aattgcacac
     7441 tcacgaatct gacagatctt gtatccactt ggaattcgac atctctagaa ctggtatcac
     7501 ttacgaaact ggtgaccacg ttggtgttta cgctgaaaac cacgttgaaa tcgttgaaga
     7561 agctggtaag ttgttgggtc actctttgga cttggttttc tctatccacg ctgacaagga
     7621 agacggttct ccattggaat ctgctgttcc accaccattc ccaggtccat gtactttggg
     7681 tactggtttg gctagatacg ctgacttgtt gaacccacca agaaagtctg ctttggttgc
     7741 tttggctgct tacgctactg aaccatctga agctgaaaag ttgaagcact tgacttctcc
     7801 agacggtaag gacgaatact ctcaatggat cgttgcttct caaagatctt tgttggaagt
     7861 tatggctgct ttcccatctg ctaagccacc attgggtgtt ttcttcgctg ctatcgctcc
     7921 aagattgcaa ccaagatact actctatctc ttcttctcca agattggctc catctagagt
     7981 tcacgttact tctgctttgg tttacggtcc aactccaact ggtagaatcc acaagggtgt
     8041 ttgttctact tggatgaaga acgctgttcc agctgaaaag tctcacgaat gttctggtgc
     8101 tccaatcttc atcagagctt ctaacttcaa gttgccatct aacccatcta ctccaatcgt
     8161 tatggttggt ccaggtactg gtttggctcc attcagaggt ttcttgcaag aaagaatggc
     8221 tttgaaggaa gacggtgaag aattgggttc ttctttgttg ttcttcggtt gtagaaacag
     8281 acaaatggac ttcatctacg aagacgaatt gaacaacttc gttgaccaag gtgttatctc
     8341 tgaattgatc atggctttct ctagagaagg tgctcaaaag gaatacgttc aacacaagat
     8401 gatggaaaag gctgctcaag tttgggactt gatcaaggaa gaaggttact tgtacgtttg
     8461 tggtgacgct aagggtatgg ctagagacgt tcacagaact ttgcacacta tcgttcaaga
     8521 acaagaaggt gtttcttctt ctgaagctga agctatcgtt aagaagttgc aaactgaagg
     8581 tagatacttg agagacgttt ggtaagttga cacaaatcgc tcttaaatat atacctaaag
     8641 aacattaaag ctatattata agcaaagata cgtaaatttt gcttatatta ttatacacat
     8701 atcatatttc tatattttta agatttggtt atataatgta cgtaatgcaa aggaaataaa
     8761 ttttatacat tattgaacag cgtccaagta actacattat gtgcactaat agtttagcgt
     8821 cgtgaagact ttattgtgtc gcgaaaagta aaaattttaa aaattagagc accttgaact
     8881 tgcgaaaaag gttctcatca actgtttaaa aggatcatga acttgcgctc aattccgcgc
     8941 agaaggcaat gctataagac ctacgtccac ggattgcgcc taagaccgga taaagcgatg
     9001 catagggtaa taactgttgc gcctaagacc ggataaagca ccgcataggg taataactga
     9061 tataattaaa ttgaagctct aatttgtgag tttagtatac atgcatttac ttataataca
     9121 gttttttagt tttgctggcc gcatcttctc aaatatgctt cccagcctgc ttttctgtaa
     9181 cgttcaccct ctaccttagc atcccttccc tttgcaaata gtcctcttcc aacaataata
     9241 atgtcagatc ctgtagagac cacatcatcc acggttctat actgttgacc caatgcgtct
     9301 cccttgtcat ctaaacccac accgggtgtc ataatcaacc aatcgtaacc ttcatctctt
     9361 ccacccatgt ctctttgagc aataaagccg ataacaaaat ctttgtcgct cttcgcaatg
     9421 tcaacagtac ccttagtata ttctccagta gatagggagc ccttgcatga caattctgct
     9481 aacatcaaaa ggcctctagg ttcctttgtt acttcttctg ccgcctgctt caaaccgcta
     9541 acaatacctg ggcccaccac accgtgtgca ttcgtaatgt ctgcccattc tgctattctg
     9601 tatacacccg cagagtactg caatttgact gtattaccaa tgtcagcaaa ttttctgtct
     9661 tcgaagagta aaaaattgta cttggcggat aatgccttta gcggcttaac tgtgccctcc
     9721 atggaaaaat cagtcaagat atccacatgt gtttttagta aacaaatttt gggacctaat
     9781 gcttcaacta actccagtaa ttccttggtg gtacgaacat ccaatgaagc acacaagttt
     9841 gtttgctttt cgtgcatgat attaaatagc ttggcagcaa caggactagg atgagtagca
     9901 gcacgttcct tatatgtagc tttcgacatg atttatcttc gtttcctgca ggtttttgtt
     9961 ctgtgcagtt gggttaagaa tactgggcaa tttcatgttt cttcaacact acatatgcgt
    10021 atatatacca atctaagtct gtgctccttc cttcgttctt ccttctgttc ggagattacc
    10081 gaatcaaaaa aatttcaaag aaaccgaaat caaaaaaaag aataaaaaaa aaatgatgaa
    10141 ttgaattgaa aagctgtggt atggtgcact ctcagtacaa tctgctctga tgccgcatag
    10201 ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc
    10261 ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt
    10321 tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag
    10381 gttaatgtca tgataataat ggtttcttag gacggatcgc ttgcctgtaa cttacacgcg
    10441 cctcgtatct tttaatgatg gaataatttg ggaatttact ctgtgtttat ttatttttat
    10501 gttttgtatt tggattttag aaagtaaata aagaaggtag aagagttacg gaatgaagaa
    10561 aaaaaaataa acaaaggttt aaaaaatttc aacaaaaagc gtactttaca tatatattta
    10621 ttagacaaga aaagcagatt aaatagatat acattcgatt aacgataagt aaaatgtaaa
    10681 atcacaggat tttcgtgtgt ggtcttctac acagacaaga tgaaacaatt cggcattaat
    10741 acctgagagc aggaagagca agataaaagg tagtatttgt tggcgatccc cctagagtct
    10801 tttacatctt cggaaaacaa aaactatttt ttctttaatt tcttttttta ctttctattt
    10861 ttaatttata tatttatatt aaaaaattta aattataatt atttttatag cacgtgatga
    10921 aaaggaccca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt
    10981 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata
    11041 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt
    11101 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc
    11161 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat
    11221 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct
    11281 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca
    11341 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg
    11401 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa
    11461 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg
    11521 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga
    11581 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg
    11641 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt
    11701 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg
    11761 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc
    11821 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca
    11881 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc
    11941 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat
    12001 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc
    12061 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg
    12121 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct
    12181 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct
    12241 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct
    12301 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg
    12361 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc
    12421 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga
    12481 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg
    12541 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta
    12601 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg
    12661 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg
    12721 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat
    12781 atcactatat gtgaaggcat ggctatggca cggcagacat tccgccagat catcaatagg
    12841 cactagcaca cggtcgaatt tccga
//
