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Wuhan pneumonia pathogen was initially identified as a new coronavirus similar to SARS

Abstract:

Important progress has been made in the etiology identification of unknown causes of viral pneumonia in the electron microscope in Wuhan. According to CCTV, as of 21:00 on January 7, a new type of coronavirus was detected in the laboratory, and the entire genome sequence of the virus was obtained. A total of 15 positive results of the new type of coronavirus were detected by nucleic acid detection. The virus was isolated from patient samples and showed a typical coronavirus appearance under an electron microscope.


Important progress has been made in the etiology identification of unknown causes of viral pneumonia in the electron microscope in Wuhan. According to CCTV, as of 21:00 on January 7, a new type of coronavirus was detected in the laboratory, and the entire genome sequence of the virus was obtained. A total of 15 positive results of the new type of coronavirus were detected by nucleic acid detection. The virus was isolated from patient samples and showed a typical coronavirus appearance under an electron microscope.


The preliminary assessment of the results of pathogen detection The expert group believes that the pathogen of this unexplained case of viral pneumonia was initially determined to be a new type of coronavirus. Tissue laboratories use genomic sequencing, nucleic acid detection, virus isolation, and other methods to etiologically detect samples from patients with alveolar lavage fluid, throat swabs, and blood. The expert group stated that the identification of the cause of an epidemic usually requires the following:


1. Suspicious pathogens must be found in patients, and pathogenic nucleic acids can be detected in clinical samples of patients;

2. Pathogens can be successfully isolated from clinical samples of patients;

3. Infecting host animals with isolated pathogens can cause the same disease symptoms. The patient's serum antibody titer during the recovery period increased four-fold, which can help identify the pathogen.

4. Finding the nucleic acid, genome and antibody evidence of the pathogen from the patient can be completed in a short time. Scientific research, such as pathogen isolation and pathogenicity identification, can take weeks. The development of specific drugs and vaccines against a new pathogen may take years to complete. The expert group believes that the pathogen of this unexplained case of viral pneumonia is initially determined as a new type of coronavirus. The next step is to conduct expert research and judgement in combination with pathogenic research, epidemiological investigation and clinical manifestations.


Additional information:

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Coronavirus is a pathogen that mainly causes respiratory and intestinal diseases. It was first isolated from chickens in 1937. In 1965, scientists isolated the first human coronavirus from a nasal wash from a common cold patient. The surface of this type of virus particle has many regularly arranged protrusions, and the entire virus particle is shaped like a crown, hence the name "coronavirus". Coronavirus only infects human, mouse, pig, cat, dog, and bird vertebrates. The SARS pathogen that erupted in 2003 is a new type of coronavirus. 


The Coronavirus family contains nearly 20 viruses of the genus α, β, γ, and δ, of which 6 are known to infect humans. Among them, 4 kinds of coronaviruses are more common in the population and have lower pathogenicity, and generally cause only minor respiratory symptoms similar to common colds. Two other coronaviruses—severe acute respiratory syndrome (SARS) coronavirus and middle eastern respiratory syndrome (MERS) coronavirus—can cause serious respiratory diseases. The new coronavirus that caused the epidemic is different from the human coronaviruses that have been discovered, and further understanding of the virus requires further scientific research.


Souce: NovoPro    2020-01-11