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  • Rhesus Osteoprotegerin/TNFRSF11B (Fc Tag) recombinant protein

Rhesus Osteoprotegerin/TNFRSF11B (Fc Tag) recombinant protein

Cat.#: 502195

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Product Information

  • Product Name
    Rhesus Osteoprotegerin/TNFRSF11B (Fc Tag) recombinant protein
  • Documents
  • Description
    Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
  • Protein name
    Uncharacterized protein
  • Protein short names
    OSTEOPROTEGERIN; TNFRSF11B; TR1; OCIF; MGC29565; OPG
  • Uniprot ID
    F7G7U5
  • Gene Name
    TNFRSF11B; EGK_19228
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus TNFRSF11B (XP_001096915.1) (Met28-Leu428) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus TNFRSF11B comprises 621 amino acids and has a calculated molecular mass of 65 KDa.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Cynomolgus Osteoprotegerin / TNFRSF11B Protein (Fc Tag) SDS-PAGE

    Cynomolgus Osteoprotegerin / TNFRSF11B Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"