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  • Human Axl Kinase (His Tag) recombinant protein

Human Axl Kinase (His Tag) recombinant protein

Cat.#: 501760

Special Price 307.5 USD

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Product Information

  • Product Name
    Human Axl Kinase (His Tag) recombinant protein
  • Documents
  • Description
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
  • Protein name
    Tyrosine-protein kinase receptor UFO
  • Protein short names
    JTK11; AXL; TYRO7; ARK; UFO; AI323647
  • Uniprot ID
    P30530
  • Gene Name
    AXL; UFO
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human AXL isoform 1 (NP_068713.2) extracellular domain (Met 1-Pro 449) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human AXL consists of 428 amino acids after removal of the signal peptide and predicts a molecular mass of 46.5 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 60-70 kDa band due to glycosylation.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Validations

    Human Axl Kinase Protein (His Tag) SDS-PAGE

    Human Axl Kinase Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"