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Product Name
Rhesus CD40/TNFRSF5 (Fc Tag) recombinant protein
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Description
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
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Protein name
Tumor necrosis factor receptor superfamily member 5 isoform 1
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Protein short names
P50; CDW40; IMD3; AI326936; T-BAM; IGM; HIGM1; CD40; TNFRSF5; BP50; GP39; MGC9013; RP23-428M13.1; TRAP
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Uniprot ID
H9ZFM8
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Gene Name
CD40
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus CD40 (NP_001252791.1) (Met1-Arg193) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus comprises 414 amino acids and has a calculated molecular mass of 46.2 KDa.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Cynomolgus / Rhesus CD40 / TNFRSF5 Protein (Fc Tag) SDS-PAGE
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"