Human RANKL/OPGL/TNFSF11 (CD254) recombinant protein

Cat.#: 502788

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Product Information

  • Product Name
    Human RANKL/OPGL/TNFSF11 (CD254) recombinant protein
  • Documents
  • Description
    Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
  • Protein name
    Tumor necrosis factor ligand superfamily member 11
  • Protein short names
    SODF; ODF; RANKL; CD254; OPGL; TNFSF11; OPTB2; OPG; LY109L; TRANCE; HRANKL2; RP11-86N24.2
  • Uniprot ID
    O14788
  • Gene Name
    TNFSF11; OPGL; RANKL; TRANCE
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TNFSF11 (O14788-2) (Gly 63-Asp 244) was expressed.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TNFSF11 consists of 182 amino acids and has a calculated molecular mass of 20.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 27 kDa due to the glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Immobilized human TNFSF11 at 10 μg/ml (100 μl/well) can bind biotinylated human TNFRSF11B-His (Cat:500115), The EC50 of biotinylated human TNFRSF11B-His (Cat:500115) is 5.7-13.4 ng/ml.
    2. The bioactivity of hRANKL was determined by measuring the ability of hRANKL to induce TRAP activity in Raw 264.7 cells. The ED50 for this effect is typically 1.5-7.5 ng/mL.
  • Validations

    Human RANKL / OPGL / TNFSF11 / CD254 Protein SDS-PAGE

    Human RANKL / OPGL / TNFSF11 / CD254 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"