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  • Human SAE1 (His & GST Tag) recombinant protein

Human SAE1 (His & GST Tag) recombinant protein

Cat.#: 500000

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Product Information

  • Product Name
    Human SAE1 (His & GST Tag) recombinant protein
  • Documents
  • Description
    SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.
  • Protein name
    SUMO-activating enzyme subunit 1
  • Protein short names
    UBLE1A; UBIQUITIN-LIKE (SENTRIN) ACTIVATING ENZYME E1A; SUMO-ACTIVATING ENZYME SUBUNIT 1; 2400010M20RIK; AW743391; HSPC140; UBIQUITIN-LIKE 1 (SENTRIN) ACTIVATING ENZYME E1A; SUMO-1 ACTIVATING ENZYME E1 N SUBUNIT; UBIQUITIN-LIKE 1-ACTIVATING ENZYME E1A; D7ERTD177E; SENTRIN/SUMO-ACTIVATING PROTEIN AOS1; UBIQUITIN-LIKE PROTEIN SUMO-1 ACTIVATING ENZYME; ACTIVATOR OF SUMO1; SUA1; 2610044L12RIK; AOS1; UBIQUITIN-LIKE 1 (SENTRIN) ACTIVATING ENZYME SUBUNIT 1; SUMO-1 ACTIVATING ENZYME SUBUNIT 1; AL033372
  • Uniprot ID
    Q9UBE0
  • Gene Name
    SAE1; AOS1; SUA1; UBLE1A
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SAE1 (Q9UBE0) (Met1-Lys346) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human SAE1 /GST chimera consists of 583 amino acids and has a calculated molecular mass of 66.3 kDa. The recombinant protein migrates as an approximately 61 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human SAE1 Protein (His & GST Tag) SDS-PAGE

    Human SAE1 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"