Mouse CXCL12 / SDF-1 beta recombinant protein

Mouse CXCL12 / SDF-1 beta recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Stromal cell-derived factor 1

IRH; TLSFB; SDF1A; TLSF-A; TLSF-B; SDF-1B; TPAR1; SDF1; CXCL12; AI174028; TLSF; TLSFA; SDF-1A; SCYB12; PBSF; SDF1B; CHEMOKINE (C-X-C MOTIF) LIGAND 12 (STROMAL CELL-DERIVED FACTOR 1)

P40224

Cxcl12; Sdf1

E. coli

A DNA sequence encoding the mature form of mouse CXCL12 (P40224-1) (Lys22-Lys89) was expressed and purified with an initial Met.

Mouse

The recombinant mouse CXCL12 consists of 69 amino acids and predicts a molecular mass of 8.1 KDa. It migrates as an approximately 8 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE