Mouse ACVR2A (His & Fc Tag) recombinant protein
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
Serine/threonine-protein kinase receptor
Protein short names
ACVR2A; TACTRII; ACVR2; ACTRIIA; ACTRII; RP23-139F8.3
A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
The secreted recombinant mouse ACVR2A/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 363 amino acids and has a calculated molecular mass of 41.4 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 55-65 kDa band in SDS-PAGE under reducing conditions.
> 97 % as determined by SDS-PAGE
Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A.
Mouse ACVR2A / ActrIIa Protein (His & Fc Tag) SDS-PAGE
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