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Product Name
Human Semaphorin 4A/SEMA4A/Semaphorin B (His Tag) recombinant protein
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Description
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).
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Protein name
Semaphorin-4A
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Protein short names
RP35; RP11-54H19.2; SEMA4A; SEMA B; SEMAB; CORD10; SEMAPHORIN-B; FLJ12287; SEMB; AI132332; SEMAPHORIN 4A
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Uniprot ID
Q9H3S1
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Gene Name
SEMA4A; SEMAB; SEMB; UNQ783/PRO1317
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SEMA4A (NP_071762.2) extracellular domain (Met 1-His 683) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SEMA4A consists of 663 amino acids and predictes a molecular mass of 73.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh SEMA4A is approximately 75-80 kDa.
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Purity
> 96 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind biotinylated mouse SEMA4D in a functional ELISA.
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Validations
Human Semaphorin 4A / SEMA4A / Semaphorin B Protein (His Tag) SDS-PAGE
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