Cart 2
  • Human SFRP1 (His Tag) recombinant protein

Human SFRP1 (His Tag) recombinant protein

Cat.#: 501914

Size:

Special Price 442.8 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human SFRP1 (His Tag) recombinant protein
  • Documents
  • Description
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
  • Protein name
    Secreted frizzled-related protein 1
  • Protein short names
    AW107218; SFRP1; FRZA; FRP1; AW742929; FRP; SFRP-1; SARP2; 2210415K03RIK; FRP-1; AW011917
  • Uniprot ID
    Q8N474
  • Gene Name
    SFRP1; FRP; FRP1; SARP2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human sFRP1 (NP_003003.3) (Met 1-Lys 314) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human sFRP1 consists of 294 amino acids after removal of the signal peptide and has a predicted molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 38 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is typically 2.5-10 μg/ml.
  • Validations

    Human sFRP1 / SARP2 Protein (His Tag) SDS-PAGE

    Human sFRP1 / SARP2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"