Human LIMP-2/SCARB2 (His & Fc Tag) recombinant protein

Human LIMP-2/SCARB2 (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.

Scavenger receptor class B, member 2, isoform CRA_a

EPM4; LGP85; LIMPII; SCARB2; CD36L2; AMRF; LIMP-2; MLGP85; SR-BII; HLGP85; 9330185J12RIK

Q14108

SCARB2; hCG_23840

Human Cells

A DNA sequence encoding the human SCARB2 (NP_005497.1) extracellular domain (Arg 27-Thr 432) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Human

The recombinant human SCARB2/Fc is a disulfide-linked homodimer. The reduced monomer consists of 653 amino acids and has a predicted molecular mass of 74.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSCARB2/Fc monomer is approximately 110-115 kDa due to glycosylation.

> 90 % as determined by SDS-PAGE

Measured by its ability to bind recombinant human RSPO1 in a functional ELISA.