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Mouse Tie2?CD202b?/TEK (Fc Tag) recombinant protein

Cat.#: 502539

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Product Information

  • Product Name
    Mouse Tie2?CD202b?/TEK (Fc Tag) recombinant protein
  • Documents
  • Description
    TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
  • Protein name
    Receptor protein-tyrosine kinase
  • Protein short names
    TIE-2; TIE2; AA517024; CD202B; VMCM1; HYK; TEK; STK1; VMCM; RP23-345A23.1
  • Uniprot ID
    B1AWS8
  • Gene Name
    Tek; mCG_122568
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Tek (NP_038718.2) (Met1-Lys744) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Tek consists 964 amino acids and predicts a molecular mass of 107.7 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized mouse ANGPT2 (Cat:501251) at 10 μg/mL (100 μL/well) can bind mouse TEK-Fc. The EC50 of mouse TEK-Fc is 0.58-1.34 μg/mL.
  • Validations

    Tek protein SDS-PAGE

    Tek protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"