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  • Rat c-Met/HGFR (Fc Tag) recombinant protein

Rat c-Met/HGFR (Fc Tag) recombinant protein

Cat.#: 502359

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Product Information

  • Product Name
    Rat c-Met/HGFR (Fc Tag) recombinant protein
  • Documents
  • Description
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • Protein name
    Receptor protein-tyrosine kinase
  • Protein short names
    RCCP2; C-MET; AUTS9; HGF; HGFR; MET; AI838057; PAR4
  • Uniprot ID
    Q2IBC7
  • Gene Name
    Met; Capza2; Cav; Cav2; Cftr; LOC500040; ST7; Wnt2; rCG_27969
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat MET (Q2IBC7) (Met1-Asn932) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat MET/Fc is a disulfide-linked homodimer. The reduced monomer comprises 1149 amino acids and has a predicted molecular mass of 128.1 kDa. The apparent molecular mass of the protein is approximately 97 and 39 kDa in SDS-PAGE under reducing conditions.
  • Purity
    (63.0+32.1) % as determined by SDS-PAGE
  • Activity
    Immobilized rat HGF (Cat:504728) at 10 μg/ml (100 μl/well) can bind Rat MET-Fc, EC50 of Rat MET-Fc is 0.02-0.05 μg/ml.
  • Validations

    Rat c-MET / HGFR Protein (Fc Tag) SDS-PAGE

    Rat c-MET / HGFR Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"