Rat EGFR/HER1/ErbB1 (His Tag) recombinant protein
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-Î±, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Receptor protein-tyrosine kinase
A DNA sequence encoding the rat EGFR (E7CXR8) (Met1-Ser646) was expressed, fused with a polyhistidine tag at the C-terminus.
The recombinant rat EGFR comprises 633 amino acids and predicts a molecular mass of 70.7 kDa. The apparent molecular mass of the recombinant protein is approximately 93-110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
> 98 % as determined by SDS-PAGE
1. Measured by its ability to bind recombinant human EGF-Fc (Cat:503608) in a functional ELISA.
2. Measured by its ability to bind recombinant mouse EGF-Fc (Cat:503939) in a functional ELISA.
Rat EGFR / HER1 / ErbB1 Protein (His Tag) SDS-PAGE
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