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  • Rabbit Anti-NMDAR2B Polyclonal Antibody

Rabbit Anti-NMDAR2B Polyclonal Antibody

Cat.#: 119048

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Special Price 372.6 USD

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Product Information

  • Product Name
    Rabbit Anti-NMDAR2B Polyclonal Antibody
  • Documents
  • Description
    Purified Rabbit Polyclonal Antibody (Pab)
  • Tested applications
    WB, IF, IHC-P
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    NMDAR2B antibody; MRD6; NR2B; hNR3; GluN2B; NMDAR2B; Glutamate receptor ionotropic antibody; NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NR3; GRIN2B antibody
  • Isotype
    Rabbit IgG
  • Clonality
    Polyclonal
  • Formulation
    Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
  • Storage instructions
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
  • Applications
    IHC-P: 1:100~1:500
  • Validations

    Formalin-fixed and paraffin-embedded rat brain labeled with Anti-NMDAR2B Polyclonal Antibody, Unconjugated(119048) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.

    Formalin-fixed and paraffin-embedded rat brain labeled with Anti-NMDAR2B Polyclonal Antibody, Unconjugated(119048) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.

  • Background
    NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"