Human S100A12 recombinant protein

Cat.#: 502704

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human S100A12 recombinant protein
  • Documents
  • Description
    S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
  • Protein name
    Protein S100-A12
  • Protein short names
    S100A12; ENRAGE; P6; CAAF1; CAGC; EN-RAGE; MRP6; CGRP
  • Uniprot ID
    P80511
  • Gene Name
    S100A12
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human S100A12 consisting of 92 amino acids and has a calculated molecular mass of 10.6 kDa. It migrates as an 10 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human S100A12 at 2 μg/ml (100 μl/well) can bind human AGER with a linear range of 0.032-20 μg/ml.
  • Validations

    Human S100A12 / CAGC / Calgranulin-C Protein SDS-PAGE

    Human S100A12 / CAGC / Calgranulin-C Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"