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  • Rat CD89/FCAR (His Tag) recombinant protein

Rat CD89/FCAR (His Tag) recombinant protein

Cat.#: 500365

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Product Information

  • Product Name
    Rat CD89/FCAR (His Tag) recombinant protein
  • Documents
  • Description
    FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
  • Protein name
    Protein Fcar
  • Protein short names
    XXBAC-BPG230H20.5; FCAR; CD89
  • Uniprot ID
    D3ZRL6
  • Gene Name
    Fcar
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat FCAR (NP_973721.1) extracellular domain (Met 1-Asn 228) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat FCAR comprises 217 amino acids and predicts a molecular mass of 24.8 kDa. The apparent molecular mass of the rat FCAR is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Rat CD89 / FCAR Protein (His Tag) SDS-PAGE

    Rat CD89 / FCAR Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"