PRKAB1 Polyclonal Antibody
Polyclonal antibody to PRKAB1
PRKAB1 antibody; AMPK antibody; HAMPKb antibody; 5'-AMP-activated protein kinase subunit beta-1 antibody
Antigen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRKAB1 (NP_006244.2).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
IF 1:50 - 1:200
Immunofluorescence - PRKAB1 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using PRKAB1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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