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  • PRKAB1 Polyclonal Antibody

PRKAB1 Polyclonal Antibody

Cat.#: 162777

Special Price 174.2 USD

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Product Information

  • Product Name
    PRKAB1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to PRKAB1
  • Tested applications
    WB, IF
  • Species reactivity
    Human
  • Alternative names
    PRKAB1 antibody; AMPK antibody; HAMPKb antibody; 5'-AMP-activated protein kinase subunit beta-1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRKAB1 (NP_006244.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • Validations

    Immunofluorescence - PRKAB1 Polyclonal Antibody

    Immunofluorescence - PRKAB1 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using PRKAB1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"