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  • Phospho-AMPKβ1-S108 pAb

Phospho-AMPKβ1-S108 pAb

Cat.#: 166489

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Product Information

  • Product Name
    Phospho-AMPKβ1-S108 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-AMPKβ1-S108
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    PRKAB1 antibody; AMPK antibody; HAMPKb antibody; 5'-AMP-activated protein kinase subunit beta-1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphorylated peptide around S108 of human AMPKβ1 (NP_006244.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - Phospho-AMPKu03b21-S108 pAb

    Western blot - Phospho-AMPKu03b21-S108 pAb

    Western blot analysis of extracts of 293 cells, using Phospho-AMPKu03b21-S108 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"