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Product Name
Human PPARG (His & GST Tag) recombinant protein
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Description
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
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Protein name
Peroxisome proliferator-activated receptor gamma
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Protein short names
PPAR-GAMMA; PPARGAMMA; PPARG2; PPARG1; NR1C3; PPAR-GAMMA2; CIMT1; GLM1; PPARGAMMA2
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Uniprot ID
P37231
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Gene Name
PPARG; NR1C3
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PPARG isoform 2 (P37231-1) (Met 1-Tyr 505) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PPARG/GST chimera consists of 742 amino acids and has a calculated molecular mass of 85.4 kDa. It migrates as an approximately 85.4 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 65 % as determined by SDS-PAGE
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Validations
Human PPARG / Nr1c3 / PPARgamma Protein (His & GST Tag) SDS-PAGE
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