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  • p53 (Phospho-Ser46) Antibody

p53 (Phospho-Ser46) Antibody

Cat.#: 119092

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Product Information

  • Product Name
    p53 (Phospho-Ser46) Antibody
  • Documents
  • Description
    Purified Rabbit Polyclonal Antibody (Pab)
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    P53 antibody; Cellular tumor antigen p53 antibody; Antigen NY-CO-13 antibody; Phosphoprotein p53 antibody; Tumor suppressor p53 antibody; TP53 antibody; P53 antibody
  • Isotype
    Rabbit IgG
  • Clonality
    Polyclonal
  • Formulation
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
  • Applications
    WB: 1:1000
  • Validations

    Western blot analysis of extracts from COLO cells and 293 cells, using p53 (Phospho-Ser46) antibody.

    Western blot analysis of extracts from COLO cells and 293 cells, using p53 (Phospho-Ser46) antibody.

  • Background
    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"