Human Optineurin / OPTN (His & GST Tag) recombinant protein

Cat.#: 502887

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Product Information

  • Product Name
    Human Optineurin / OPTN (His & GST Tag) recombinant protein
  • Documents
  • Description
    Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
  • Protein name
    Optineurin
  • Protein short names
    HUNTINGTIN-INTERACTING PROTEIN 7; ALS12; HUNTINGTIN YEAST PARTNER L; TFIIIA-INTP; NRP; HUNTINGTIN INTERACTING PROTEIN L; FIP2; OPTIC NEUROPATHY-INDUCING PROTEIN; E3-14.7K-INTERACTING PROTEIN; TRANSCRPTION FACTOR IIIA-INTERACTING PROTEIN; TRANSCRIPTION FACTOR IIIA-INTERACTING PROTEIN; FIP-2; HYPL; RP23-379M5.2; 4930441O07RIK; NEMO-RELATED PROTEIN; HIP7; TUMOR NECROSIS FACTOR ALPHA-INDUCIBLE CELLULAR PROTEIN CONTAINING LEUCINE ZIPPER DOMAINS; OPTINEURIN; HIP-7; RP11-730A19.1; OPTN; GLC1E
  • Uniprot ID
    Q96CV9
  • Gene Name
    OPTN; FIP2; GLC1E; HIP7; HYPL; NRP
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human OPTN (NP_068815.2) (Met1-Ile577) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human OPTN chimera consists of 814 amino acids and has a calculated molecular mass of 93.7 kDa. The recombinant protein migrates approximately 94 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Validations

    Human Optineurin / OPTN Protein (His & GST Tag) SDS-PAGE

    Human Optineurin / OPTN Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"