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  • Human PBEF / Visfatin / NAMPT (His & GST Tag) recombinant protein

Human PBEF / Visfatin / NAMPT (His & GST Tag) recombinant protein

Cat.#: 502715

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Product Information

  • Product Name
    Human PBEF / Visfatin / NAMPT (His & GST Tag) recombinant protein
  • Documents
  • Description
    Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
  • Protein name
    Nicotinamide phosphoribosyltransferase
  • Protein short names
    PBEF; NAMPRTASE; VISFATIN; 1110035O14RIK; VF; PBEF1; AI314458; DKFZP666B131; AI480535; MGC117256
  • Uniprot ID
    P43490
  • Gene Name
    NAMPT; PBEF; PBEF1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human NAMPT (P43490) (Met 1-His 491 was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human NAMPT/GST chimera consists of 728 amino acids and has a calculated molecular mass of 83.3 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human PBEF / Visfatin / NAMPT Protein (His & GST Tag) SDS-PAGE

    Human PBEF / Visfatin / NAMPT Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"