Human Nicastrin/NCSTN (His Tag) recombinant protein

Cat.#: 502728

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Product Information

  • Product Name
    Human Nicastrin/NCSTN (His Tag) recombinant protein
  • Documents
  • Description
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
  • Protein name
    Nicastrin
  • Protein short names
    KIAA0253; D1DAU13E; RP11-517F10.1; NCSTN; NCT; AA727311; APH2; NICASTRIN; 9430068N19RIK; MKIAA0253
  • Uniprot ID
    Q92542
  • Gene Name
    NCSTN; KIAA0253; UNQ1874/PRO4317
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human NCSTN (NP_056146.1) extracellular domain (Met 1-Glu 669) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human NCSTN consists of 647 amino acids and predictes a molecular mass of 72.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NCSTN is approximately 110-120 kDa due to glycosylation.
  • Purity
    > 93 % as determined by SDS-PAGE
  • Validations

    Human Nicastrin / NCSTN Protein (His Tag) SDS-PAGE

    Human Nicastrin / NCSTN Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"