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  • NEURL antibody
  • NEURL antibody

NEURL antibody

Cat.#: 113121

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Product Information

  • Product Name
    NEURL antibody
  • Documents
  • Description
    NEURL Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, MCF7 cells, Y79 cells. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 60-62 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    bA416N2.1 antibody; h neu antibody; h neuralized 1 antibody; neu antibody; neu 1 antibody; Neuralized like protein 1A antibody; NEURL antibody; NEURL1 antibody; NEURL1A antibody; RING finger protein 67 antibody; RNF67 antibody
  • Isotype
    IgG
  • Preparation
    This antibody was obtained by immunization of NEURL recombinant protein (Accession Number: BC026336). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113121(NEURL antibody) at dilution of 1:800

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113121(NEURL antibody) at dilution of 1:800

    IP Result of anti-NEURL (IP:Catalog No:113121, 4ug; Detection:Catalog No:113121 1:600) with mouse brain tissue lysate 2560ug.

    IP Result of anti-NEURL (IP:Catalog No:113121, 4ug; Detection:Catalog No:113121 1:600) with mouse brain tissue lysate 2560ug.

  • Background
    NEURL(Neuralized-like protein 1A) is also named as NEURL1, NEURL1A, RNF67.Neurl1 is a RING-dependent E3 ubiquitin ligase that can regulate Notch signaling in mammals and it expression promotes lysosomal degradation of Jagged1 in cells and blocks signaling from Jagged1-expressing cells to neighboring Notch-expressing cells. Neurl-dependent turnover of Jagged1 and inhibition of Notch signaling depends upon N-terminal myristoylation and plasma membrane localization of Neurl1(PMID:18077452).This antibody is specific to NEURL.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"