Human CCN3 / NOV (IGFBP9) (His Tag) recombinant protein

Cat.#: 500064

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Product Information

  • Product Name
    Human CCN3 / NOV (IGFBP9) (His Tag) recombinant protein
  • Documents
  • Description
    Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development , and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.
  • Protein name
    Nephroblastoma overexpressed gene, isoform CRA_a
  • Protein short names
    IGFBP9; IGFBP-9; CCN3; IGF-BINDING PROTEIN 9; C130088N23RIK; IBP-9; NOV; NOVH
  • Uniprot ID
    P48745
  • Gene Name
    NOV; hCG_21266
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the full length of human NOV (NP_002505.1) (Met 1-Met 357) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human NOV consists of 337 amino acids and predicts a molecular mass of 37 kDa. It migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 94 % as determined by SDS-PAGE
  • Activity
    Measured by the ability of the immobilized protein to support the adhesion of Balb/3T3 mouse embryonic fibroblast cells. When cells are added to CCN3 coated plates (10 μg/ml, 100 μl/well), >50% cells will adhere specifically after 60 minutes at 37 ℃.
  • Validations

    Human CCN3 / NOV Protein (His Tag) SDS-PAGE

    Human CCN3 / NOV Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"