Mouse TREM-2/TREM2 (Fc Tag) recombinant protein

Cat.#: 503714

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse TREM-2/TREM2 (Fc Tag) recombinant protein
  • Documents
  • Description
    Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
  • Protein name
    Triggering receptor expressed on myeloid cells 2
  • Protein short names
    TREM2A; TREM-2; TREM2B; TREM2C
  • Uniprot ID
    Q99NH8
  • Gene Name
    Trem2; Trem2a; Trem2b; Trem2c
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Trem2 (NP_112544.1) (Met1-Pro168) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Trem2 consists 389 amino acids and predicts a molecular mass of 43.4 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Mouse TREM-2 / TREM2 Protein (Fc Tag) SDS-PAGE

    Mouse TREM-2 / TREM2 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"