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  • Mouse Tigit/Vstm3 (His tag) recombinant protein

Mouse Tigit/Vstm3 (His tag) recombinant protein

Cat.#: 518700

Special Price 265.0 USD

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Product Information

  • Product Name
    Mouse Tigit/Vstm3 (His tag) recombinant protein
  • Documents
  • Description
    T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
  • Protein name
    T cell immunoreceptor with Ig and ITIM domains(Tigit)
  • Protein short names
    Vstm3
  • Uniprot ID
    P86176
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Tigit/Vstm3 Gly26-Phe135 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Tigit/Vstm3 (His tag) recombinant protein

    Mouse Tigit/Vstm3 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"