Mouse Tie2?CD202b?/TEK (His Tag) recombinant protein

Mouse Tie2?CD202b?/TEK (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

Angiopoietin-1 receptor

VMCM1; HYK; CD202B; AA517024; TIE2; TIE-2; RP23-345A23.1; VMCM; STK1; TEK

Q02858

Tek; Hyk; Tie-2; Tie2

Human Cells

A DNA sequence encoding the mouse TEK (Q02858) (Met1-Lys744) was expressed with a C-terminal polyhistidine tag.

Mouse

The recombinant mouse TEK comprises 737 amino acids and has a predicted molecular mass of 82.4 kDa. The apparent molecular mass of the protein is approximately 91 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 99 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized mouse TEK-His (Cat: 503356) at 10 μg/ml (100 μl/well) can bind human Ang2-Fc (Cat: 503602) with a linear range of 6.25-200 ng/ml.