Mouse SCARB1 (His & Fc Tag) recombinant protein

Cat.#: 504110

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Product Information

  • Product Name
    Mouse SCARB1 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
  • Protein name
    Scarb1 protein
  • Protein short names
    MGC138242; SR-B1; SR-BI; CD36; HDLQ1; CD36L1; HLB398; SRBI; CLA-1; CLA1; D5ERTD460E; HDLQTL6; SCARB1; SRB1; MSR-BI; AI120173
  • Uniprot ID
    Q61009
  • Gene Name
    Scarb1; mCG_16968
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of mouse SRB1 (NP_058021.1) extracellular domain (Pro 33-Val 440) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse SRB1/Fc is a disulfide-linked homodimer The reduced monomer comprises 656 amino acids with a predicted molecular mass of 74 kDa. As a result of glycosylation, it migrates as an approximately 115-120 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse SCARB1 / CD36L1 / CLA-1 Protein (His & Fc Tag) SDS-PAGE

    Mouse SCARB1 / CD36L1 / CLA-1 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"