Mouse MAG/GMA/Siglec-4 (His Tag) recombinant protein

Cat.#: 504370

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Product Information

  • Product Name
    Mouse MAG/GMA/Siglec-4 (His Tag) recombinant protein
  • Documents
  • Description
    The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.
  • Protein short names
    SIGLEC-4A; S-MAG; MGC123387; GMA; SIGLEC4A
  • Uniprot ID
    P20917
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Mag (NP_034888.1) (Met1-Pro516) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Mag consists of 508 amino acids and predicts a molecular mass of 56.3 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Mouse MAG / GMA / Siglec-4 Protein (His Tag)

    Mouse MAG / GMA / Siglec-4 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"