Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.

lymphotoxin B receptor(Ltbr)

Tnfcr; Tnfrsf3

P50284

Human Cells

A DNA sequence encoding the Mouse Ltbr/Tnfcr/Tnfrsf3 Ser28-Pro218 is expressed with a Fc tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.