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  • Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

Cat.#: 519727

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Product Information

  • Product Name
    Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein
  • Documents
  • Description
    It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
  • Protein name
    lymphotoxin B receptor(Ltbr)
  • Protein short names
    Tnfcr; Tnfrsf3
  • Uniprot ID
    P50284
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Ltbr/Tnfcr/Tnfrsf3 Ser28-Pro218 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

    Mouse Ltbr/Tnfcr/Tnfrsf3 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"