Mouse Il5ra/Il5r (His tag) recombinant protein

Cat.#: 519225

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Product Information

  • Product Name
    Mouse Il5ra/Il5r (His tag) recombinant protein
  • Documents
  • Description
    Interleukin 5 Receptor alpha (IL-5 Rα), also known as CD125, is a hematopoietin receptor that plays a dominant role in eosinophil biology. Mature mouse IL-5 Rα consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four cysteine motif, a 22 aa transmembrane segment, and a 54 aa cytoplasmic domain. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Rα and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GM-CSF. IL-5 Rα binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling-competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5 Rα followed by eosinophilic differentiation and activation. IL-5 Rα also promotes the differentiation of basophils and B cells. Exposure of mature eosinophils to IL-5 attenuates their IL-5 responsiveness by inducing the down-regulation of surface IL-5 Rα and increased production of soluble IL-5 Rα.
  • Protein name
    interleukin 5 receptor, alpha(Il5ra)
  • Protein short names
    Il5r
  • Uniprot ID
    P21183
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Il5ra/Il5r Asp18-His339 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Il5ra/Il5r (His tag) recombinant protein

    Mouse Il5ra/Il5r (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"