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  • Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 recombinant protein

Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 recombinant protein

Cat.#: 519013

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Product Information

  • Product Name
    Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 recombinant protein
  • Documents
  • Description
    Mouse Interleukin-36 alpha(Il-36a)is a member of the IL-1 family.IL¬1α,IL¬1β and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is expressed in many cells, including monocytes, B cells, and T cells, immune system and fetal brains. Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
  • Protein name
    interleukin 1 family, member 6(Il1f6)
  • Protein short names
    Fil1e; Il1e; Il1f6; Il1h1
  • Uniprot ID
    Q9JLA2
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 Arg8-His160 is expressed.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 recombinant protein

    Mouse Il36a/Fil1e/Il1e/Il1f6/Il1h1 recombinant protein

  • Antibodies
  • Recombinant Proteins
  • cDNA Clones

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"