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Mouse IL-17R/IL-17RA ?CD217? (Fc Tag) recombinant protein

Cat.#: 503529

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Product Information

  • Product Name
    Mouse IL-17R/IL-17RA ?CD217? (Fc Tag) recombinant protein
  • Documents
  • Description
    Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
  • Protein name
    Interleukin-17 receptor A
  • Protein short names
    HIL-17R; CDW217; IL17R; AW538159; IL-17RA; IL-17R; VDW217; MGC10262; CD217; CANDF5; IL17RA
  • Uniprot ID
    Q60943
  • Gene Name
    Il17ra; Il17r
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse IL17RA (Q60943)(Met1-Trp322) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse IL17RA/Fc is a disulfide-linked homodimer. The reduced monomer comprises 532 amino acids and has a predicted molecular mass of 60.3 kDa. The apparent molecular mass of the protein is approximately 67-77 and 118 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    (14.8+80.1) % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized mouse IL17A (Cat:503385) at 10 μg/ml (100 μl/well) can bind mouse IL17RA-Fc (cat: 503529), The EC50 of mouse IL17RA-Fc (cat: 503529) is 0.28-0.64 μg/ml.
  • Validations

    Mouse IL17RA / IL17R / CD217 Protein (Fc Tag) SDS-PAGE

    Mouse IL17RA / IL17R / CD217 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"