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  • Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

Cat.#: 519248

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Product Information

  • Product Name
    Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein
  • Documents
  • Description
    Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, monocytes, and dendritic cells. It binds to ICOS on activated T cells, leading to both positive and negative effects on immune responses including its own down-regulation. The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells, plasma cells, follicular helper T cells and germinal centers. B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses, limiting Th17 responses, and promoting eosinophilic infiltration into the lung. Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness, promotes the development of inhalational tolerance, and impairs antitumor immunity. In the thyroid, B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones.
  • Protein name
    icos ligand(Icosl)
  • Protein short names
    B7h2; B7rp1; Icosl
  • Uniprot ID
    Q9JHJ8
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Icoslg/B7h2/B7rp1/Icosl Glu47-Lys279 is expressed fused with a 6His tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

    Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"