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  • Mouse CSNK2A1 (His & GST Tag) recombinant protein

Mouse CSNK2A1 (His & GST Tag) recombinant protein

Cat.#: 504296

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Product Information

  • Product Name
    Mouse CSNK2A1 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via th phosphorylation of Akt.
  • Protein name
    Casein kinase II subunit alpha
  • Protein short names
    CSNK2A3; RP23-452D3.3; MGC102141; CSNK2A1-RS4; CKII; CK2A1; CK II ALPHA; CSNK2A1
  • Uniprot ID
    Q60737
  • Gene Name
    Csnk2a1; Ckiia
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse CSNK2A1 (Q60737) (Met1-Gln391) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse CSNK2A1/GST chimera consists of 628 amino acids and has a calculated molecular mass of 72.9 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    The specific activity was determined to be 34 nmol/min/mg using casein as substrate.
  • Validations

    Mouse CSNK2A1 / CK2A1 Protein (His & GST Tag) SDS-PAGE

    Mouse CSNK2A1 / CK2A1 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"