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  • Mouse CD33 recombinant protein (C-cleavage)
  • Mouse CD33 recombinant protein (C-cleavage)

Mouse CD33 recombinant protein (C-cleavage)

Cat.#: 514736

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Product Information

  • Product Name
    Mouse CD33 recombinant protein (C-cleavage)
  • Documents
  • Description
    Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein name
    Myeloid cell surface antigen CD33
  • Protein short names
    gp67,Siglec-3
  • Uniprot ID
    Q63994
  • Gene Name
    Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; CD antigen CD33
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Cd33 (NP_067268.1) (Met1-Glu240) was expressed with six amino acids (LEVLFQ) at the C- terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Cd33 consists of 231 amino acids and predicts a molecular mass of 25.6 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Mouse CD33/Siglec-3 Protein 15524

    Mouse CD33/Siglec-3 Protein 15524

    Mouse CD33 / Siglec-3 Protein

    Mouse CD33 / Siglec-3 Protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"