Mouse CD32/Fc gamma RII/FCGR2 (His & AVI Tag) recombinant protein

Cat.#: 503525

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Product Information

  • Product Name
    Mouse CD32/Fc gamma RII/FCGR2 (His & AVI Tag) recombinant protein
  • Documents
  • Description
    Receptors for Fc portion of IgG (Fcγ Rs) are members of the Ig superfamily, and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). CD32 protein is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94-99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. CD32 is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production.
  • Protein name
    Low affinity immunoglobulin gamma Fc region receptor II
  • Protein short names
    RII; LY-17; FCGR2A; CDW32; FCΓ FCGR2; FCGR2B; CD32B; CD32A; FCGR; IGFR2; FCG2; LYM-1; LY-M20; FCGRII; CD32
  • Uniprot ID
    A0A0B4J1E6
  • Gene Name
    Fcgr2b
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Arg 217) of mouse FGGR2B (NP_001070657.1) as fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse FGGR2B consists of 212 amino acids and has a predicted molecular mass of 23.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FGGR2B is approximately 38-43 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind human IgG1 in a functional ELISA.
    2. Labeling ratio of biotin to protein: 0.5
  • Validations

    Mouse CD32 / FCGR2B Protein (His & AVI Tag), Biotinylated SDS-PAGE

    Mouse CD32 / FCGR2B Protein (His & AVI Tag), Biotinylated SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"