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  • Mouse Ccl2/Je/Mcp1/Scya2 (His tag) recombinant protein

Mouse Ccl2/Je/Mcp1/Scya2 (His tag) recombinant protein

Cat.#: 518115

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Product Information

  • Product Name
    Mouse Ccl2/Je/Mcp1/Scya2 (His tag) recombinant protein
  • Documents
  • Description
    C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.
  • Protein name
    chemokine (C-C motif) ligand 2(Ccl2)
  • Protein short names
    Je; Mcp1; Scya2
  • Uniprot ID
    P10148
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Ccl2/Je/Mcp1/Scya2 Gln24-Asn148 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Ccl2/Je/Mcp1/Scya2 (His tag) recombinant protein

    Mouse Ccl2/Je/Mcp1/Scya2 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"